Clophosome®-A-Clodronateliposomes(Anionic)
Clophosome®-A,negatively-chargedclodronateliposomes,offerssuperiorefficiencyofmacrophagedepletion.ClodronatemoleculesareencapsulatedinLUVliposomesforsuperioractivity,physicalandchemicalstABIlity,andconvenienceofuse.Itisformulatedtoanexceptionallyhighclodronate/lipidratio.FreeclodronateiscleanedoutandtheLiposomalencapsulationefficiencyofclodronateismorethan90%.Clophosomeliposomesremainhomogenousevenafterlongtermstorageinfridge.Itisnotviscousandeasytoinjectevenwithfineneedles.Itismanufacturedsterileforlongtermshelf-life.
Theproductissuitablefordosingwithvariousroutesincludingintravenous,intraperitoneal,subcutaneous,intranasal,intratrachealandetc.Wehaveachieved>90%depletioninsplenicmacrophages(redpulpmacrophages)24hoursafterasingle0.2mLintravenousinjection.Astartingdoseof0.15-2mL(i.v.ori.p.)for20-25ganimalbodyweightisrecommendedforgoodconsistencyinmacrophagedepletion.Optimizationisrecommendedforspecificapplications.
Specifications
Productname:Clophosome®-A
Productcode:F70101C-A
Active:clodronatedisodium.CAS:22560-50-5,7mg/mL
Lipidcomposition:phosphatidylglycerol,phosphatidylcholineandcholesterol
Bulksolution:phosphatebufferedsaline(20mMsodiumphosphate,09wt%NaCl),pH7.0-7.5
Shelf-life:6monthsguaranteedforunopenedvialsat2-8degreeC(guaranteedstartingfromthedateofdelivery,replacementonly)
SeesampleCofA
