PEGylated Liposomal Topotecan HCl

TopotecanHCl is loaded into PEGylated liposomes composed of HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) with ammonium sulfate gradient by the active loading approach. The liposomes are produced by the extrusion method. The product is ofhigh quality with Narrow particle size distribution and high drug encapsualtion efficiency.

Product For Research only and NOT for Human Use

Specifications

Product code: F30204-TT

Lipid composition: HSPC/CHOL/mPEG2000-DSPE (50:45:5mol/mol)

Lipid concentration: 20.0 mM

TopotecanHCl: 2.0 mg/mL

Encapsulation efficiency: > 95%

Loading battery: 250 mMammonium sulfate

Mean particle size: 100 nm (80-110 nm)

External solution: 10% sucrose, 20 Mm HEPES, pH 7.0

Shelf-life:3 months, storage:2-8 degree C

Topotecan:Synonym: 9-​[(dimethylamino)​methyl]​-​10-​hydroxy-​(20S)​-​camptothecin hydrochloride hydrate

CAS Number: 123948-87-8 (free base)

HSPC: hydrogenated phosphatidylcholine (Soy)

CHOL: cholesterol

mPEG2000-DSPE: 18:0 PEG2000 PE:1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]