FormuMax Scientific公司位于美国加州硅谷，是一家致力于为药物和生物技术研究提供制剂支持的专业公司。FormuMax拥有具有世界一流水平的药物传输技术团队，可以为基础研究、制剂可行性和客服定制制剂提供服务，尤其在基于脂质体制剂技术的特殊化合物传输方面有独特的优势和经验。

http://www.liposomeexpert.com

Clophosome氯膦酸二钠脂质体（中性）Clophosome，氯膦酸二钠脂质体，能高效地耗竭体内巨噬细胞。氯膦酸二钠分子被封装于小型多层脂质体中（MLV），具有高活性、理化稳定性、使用方便的特点。该剂型具有十分高的氯膦酸二钠/脂质比率。游离的氯膦酸二钠被清除，使得脂质体包封率超过90%。即使在冰箱中长期贮存后，该脂质体仍能保持均一悬浮状态。该品不粘稠，易于注射，且经过无菌过滤，保质期长。适用于多种给药途径，包括静脉注射、腹腔注射、皮下注射、鼻内给药、气管给药等。在单次静脉注射0.2ml 24小时后，脾脏内巨噬细胞（红髓巨噬细胞）消除率为80-90%。为保证巨噬细胞耗竭的良好的一致性，对于体重为20-25g的动物，建议起始剂量为0.15-0.2ml（i.v.或i.p.）。我们建议您根据您的具体用途加以优化。产品说明产品编号：F70101C-N商品名：Clophosome有效成分：氯膦酸二钠CAS：22560-50-5脂质组成：卵磷脂和胆固醇总体容液：磷酸盐缓冲生理盐水（20mM磷酸钠，10%蔗糖），pH7.0-7.5稳定性：密封瓶中保存6个月

Standard Clophosome®

The standard Clophosome® contains 7 mg/mL of clodronate and could be dosed as recommended. For your convenience, the Clophosome® products are provided in various combo kits and vial sizes (2mL and 10mL). Evaluation samples are also available upon request. See below for results and product details.

Standard Clophosome®

Fluorescent Control Liposomes for Clophosome®

Clophosome Product Brochure

Product sheet for Clophosome®

Product Sheet for Clophosome®- A

Product sheet for lyophilized Clophosome®

Product sheet for lyophilized Clophosome®- A

MSDS

IMPORTANT NOTES FOR USING CLOPHOSOMES

CLEAN with alcohol and DO NOT reuse the needles

It is very important to follow the instruction, particularly for long-term macrophage depletion (more than a week). Animals become sensitive to infection when macrophages are depleted and their immune system is compromised. Animal sickness and even death may result if they are handled improperly. It is extremely important to conduct the injection in a clean environment. Withdraw the liposomes through the rubber stopper (clean with alcohol first) with a new sterile needle. Always clean the injection site with alcohol and use a new and sterile needle for each injection. Keep the animal cages clean. Open the vials in a biological safety cabinet (BSC hood) and DO NOT contaminate the Clophosomes.

A good practice is to include a few extra animals for long-term experiments, as occasional animal death may occur. Test with a small group of animals first if you are a new user or using a new administration regimen. Treated properly these animals (mice) could survive for over a month even with twice-a-week injection of our clodronate liposomes.